Capo on 3 - These chords work ok for this Biochemistry-ised version of the Welsh battle song.
[Verse 1]
G C G Em
If you gobble tagliatelli,
C Am D
Chicken soup with vermcilli,
G C G Em
You’ll acquire a sagging belly –
G D G
What’s the use of that?
[Verse 2]
G C G Em
If your intake’s calorific,
C Am D
Guzzling beer till soporific,
G C G Em
Possibly you’ll feel terrific,
G D G
But you’ll end up fat.
[Refrain 1]
D
Fat against starvation;
G
Fat for insulation;
G
If you sit hard you’ll bounce on lard
G
Which substitutes in females for inflation.
C G Am G
Fat provides when you are needing
Am D
Glucogenic when you’re seeding
G C G Em
Product of excessive feeding
G D G
Hail Adipocyte!
[Verse 3]
G C G Em
That cell does not believe in spurning
C Am D
Excess food that it's not burning.
G C G Em
Therefore carboyhdrate turning
G D G
To an acetyl
[Verse 4]
G C G Em
Trapped inside the matrix spaces
C Am D
CoA esters in such places
G C G Em
Need to show some fancy paces
G D G
And a dash of style
[Refrain 2]
D
Hence, citrate formation,
G
Anion translocation
G
(The other way, goes malate,say)
G
And cleavage then reverses condensation
C G Am G
Acetyl CoA formation
Am D
Outside ready for ligation
G C G Em
Now forms by carboxylation
G D G
Malonyl CoA.
[Verse 5]
G C G Em
Fatty acid synthetase is
C Am D
So complex that it amazes
G C G Em
By the subtle interphases
G D G
Between every piece.
[Verse 6]
G C G Em
Twice we find a thiol centre
C Am D
Through which all new carbons enter
G C G Em
Structured so as to prevent a
G D G
Premature release
[Refrain 3]
D
First one on the scene I'll
G
Say is pantothenyl
G
On ACP, as we shall see,
G
A carrier of acyl groups, but meanwhile
C G Am G
There's an outer thiol station
Am D
Much involved in condensation
G C G Em
Starts off with an acylation
G D G
By an acetyl.
[Verse 7]
G C G Em
Firstly, now that's all been stated
C Am D
A-P-Cs malonylated,
G C G Em
Which of course is integrated
G D G
With CoA release.
[Verse 8]
G C G Em
Now there is a new ligation
C Am D
Paid by decarboxylation
G C G Em
Acetyl from outer station
G D G
Makes a C4 piece.
[Refrain 3]
D
Really it's quite neat, oh!
G
Nature doesn't veto
G
What we've just seen, on methylene
G
Gives ACP with acyl Beta keto,
C G Am G
A-C-P now acts as hinging,
Am D
Keto acyl is now swinging
G C G Em
Till its keto group it's bringing
G D G
To the reductase.
[Verse 9]
G C G Em
If when we're metabolising
C Am D
It's for biosynthesising
G C G Em
N-A-D-P-H arising
G D G
Has a ready use.
[Verse 10]
G C G Em
Pentose phosphate H-extraction,
C Am D
Also malic enzyme action,
G C G Em
All in cytosolic fraction,
G D G
All set to reduce
[Refrain 4]
D
Keto group reduction,
G
Hydroxy construction
G
On A-C-P, so never free,
G
Hydroxy Beta butyryl production,
C G Am G
Next we swing to dehydration,
Am D
Enoyl A-C-P formation,
G C G Em
Then a new hydrogenation
G D G
Saturates the chain.
[Verse 11]
G C G Em
Acyl fate is now transferal
C Am D
To free thiols peripheral,
G C G Em
Pantothenyls thus prepare all,
G D G
For the next attack,
[Verse 12]
G C G Em
As in circuit we've just ended
C Am D
Malonyl is apprehended,
G C G Em
A-C-P again appended,
G D G
C4 now passed back,
[Refrain 5]
D
Bicarb, generating,
G
C6 thus creating,
G
Again we've got, on Beta spot,
G
A keto in the chain we're saturating,
C G Am G
That's reduced, then dehydrated,
Am D
Double bond eliminated,
G C G Em
Now repeat, till we've created
G D G
Palmitoyl CoA!